Jinxi-Nancheng metamorphic migmatite zone composed mainly of Jinxi igneous mass amd controlled by various ductile shear zones is a multi-facies, multi_type and progressive metamorphic zone. On the basis of a comprehensive petrological and mineralogical study of Jinxi_Nancheng metamorphic migmatite zones, their Nd-Sr-Pb-O isotopic geochemistry hasbeen investigated in detail. The initial Nd and Sr isotopic compositions of migmatites and granites are 0.511689~0.511853 and 0.74864~0.75257 respectively.δ18O values of migmatites and granites are 10.23‰~14.89‰, similar to theδ18O values of high O granites(>10‰).Below the evolution line of sericite schist of folded_basement in theεNd-Tevolution diagram,initial Nd isotopic composition of migmatites and granites is apparently located in the evolutionarea of granulitite and schist of crystalline-basement. Their contents of radiogenic Pb are relatively low, withμbeing 10.07~10.4, and their Pb isotopic compositions are above the evolution line of the upper crust. The above features show that migmatites and granites in JinxiNancheng migmatite zone are formed by partial remelting of O_rich and highly_matured granulitite and schist.