The mutagenicity of inhalable mineral granules (IMG) and interaction with Epidermis staphylococcus, E. coli were studied by Ames test to analyze whether IMG and IMG/body normal flora complex has mutagenicity. The results show that Ames test of the quartz and quartz/E. coli complex on TA98 and TA100 strains assumes positive reaction, Ames test of quartz/epidermis staphylococcus complex on TA98 strains assumes position reaction, whereas Ames test of montmorillonite, calcite, albite and complex from interaction with body normal flora exhibits negative reaction, which suggests that the quartz has direct mutagenic effect, quartz/body normal flora complex still has mutagenicity, but the mechanism of the phenomenon that base replacement mutation effects of quartz disappeared after interaction with Epidermis staphylococcus needs further research.