Located at the junction of the southeastern margin of the North China Craton and the northeastern section of the Dabie-Sulu orogenic belt, the Jiaodong area is an ideal place for studying the transformation of regional tectonic mechanism and craton destruction. In this paper, the authors chose the Late Mesozoic granite as the research object, and carried out detailed petrographic, petrogeochemical, zircon LA-ICP-MS U-Pb geochronological and Sr-Nd isotope studies, focusing on the origin and evolution history of magma and geodynamic mechanism of regional diagenesis and mineralization. The results show that the emplacement ages of Jurassic continental crust remelted Linglong-type granite, Cretaceous crust-mantle mixed Guojialing-type granite and Weideshan-type granite are 163.2~157.9 Ma, 132.9~130.0 Ma, and 121.3~116.7 Ma, respectively, and the emplacement ages of Cretaceous Laoshan-type granite and vein rock are 125.0 Ma and 120.7 Ma, respectively, which are basically in line with the previous age test data. From Jurassic to Early Cretaceous, the chemical composition of granites evolved from high-potassium calc-alkaline series to shoshonite series, i.e., from peraluminous to metaluminous, trace element content evolved from high Ba-Sr to low Ba-Sr and from high Sr, low Y to low Sr and high Y, REE varied from no or weak positive Eu anomaly to significant negative Eu anomaly, and the type of granites varied from S-type to I-type and A-type. It shows the evolution trend from EM2 enriched mantle to EM1 enriched mantle, from enrichment to depletion or from lithosphere to asthenosphere. The Jiaodong area in the Late Mesozoic experienced the transformation from North China-Yangtze tectonic system to Eurasian-Pacific tectonic system and from compression mechanism to extension mechanism. The strong thermal-uplift extension structure in Early Cretaceous provided favorable conditions for large-scale gold mineralization.