The intermediate-acid intrusions in the northern part of Anhui Province of Xu-Su arc were formed by multi-stage magma, and a series of skarn (Fe) -Au-Cu-(Mo) and Fe-Cu deposits related to these intermedi-ate-acid intrusive rocks have been developed. This paper studied the zircon U-Pb age of diorite porphyrite which hosts the Wangchang skarn-type iron deposit, and Re-Os isotopic age of the molybdenite in the larg-est skarn-type gold deposit in the area (Yangqiaozi Au-Cu deposit). The LA-ICP-MS U-Pb weighted age of the Wangchang diorite porphyrite zircon is 132±1.9Ma, and the Re-Os isochron age of the molybdenite in Yangqiaozi deposit is 130±3.2 Ma. This paper systematically summerized the diagenetic age, mineraliza-tion type and metallogenic regularity in the area. It is considered that the magmatic rocks in the area can be divided into four stages, and the deposits can be divided into four types. Specifically, the first stage mag-matic rocks are early Neoproterozoic mafic intrusive rocks (diabase), which are related to the diamond de-posits. The second stage magmatic rocks are intermediate acid intrusive rocks in the early Jurassic. The third stage magmatic rocks are the Early Cretaceous intermediate-acid intrusive rocks, which are related to skarn type Fe deposits and skarn type (Fe)-Au- Cu - (Mo) deposits. The fourth stage is late Early Creta-ceous acid intrusive rocks. The magmaic Cu-Ni deposits related to mafic intrusive rocks have been discov-ered, but there is no chronological research reported yet. The Fe and Au-Cu mineralization related to in-termediate acid intrusive rocks have been widely devoloped, but just a few Cu-Ni and diamond mineraliza-tion related to mafic intrusive rocks have been discovered in the in the northern part of Anhui Province of Xu-Su arc. The magmatic rocks in the study area were formed in the extensional structural environment of the North China Craton, but are controlled by different geological events. The large-scale diagenesis and mineralization ages in the area are concentrated in the Early Cretaceous, which may be related to the de-struction of the lithosphere of the North China Craton. The chronological and geochemical data of mag-matic rocks and mineralization indicate that there may be a hydrothermal gold polymetallic deposit similar to the Jiaodong area in the deep Xu-Su arc area, which provides a reference for future prospecting in this area.