The purpose of this paper is to discuss the genetic relation between different lithofacies and tectonic setting of formation in the Huanggangliang volcanic-extrusive uplift. It is composed of the rhyolitic crystalline tuff of the ash flow facies, the dome of the extrusive facies (rhyolite porphyroclastic lava), porphyritic monzogranite of the superficial intrusive facies. Their SHRIMP zircon U-Pb ages are 140.27 0.93Ma, 140.41 0.92Ma and 141.75 respectively, which were produced by magmatic activities in Early Cretaceous. The isotopic ages of the three lithofacies are consistent within the error range, indicating that there is no obvious discontinuity between the three lithofacies, and they are the products of continuous action of thick rich crystal magma (crystal mush). These volcanic-intrusive complexes belong to the high-K calc-alkaline series chemically, and are mainly peraluminous and quasi-aluminous rocks. The contents of SiO2 and K2O in magmatic products decreased continuously from early to late, and there is a certain complementary relationship between the compositions of different lithofacies, suggesting that it may be discharged/emplaced layer by layer by magma chamber of composition zonation, and the residual magma is filled into the ring fissure of volcanic root and surrounding to form porphyritic monzogranite-quartz monzoite. The volcano-intrusive complex have the characteristics of A-type granite, which are characterized by LILE enrichment (Rb,Th,U) and HFSE (Ti,Nb,Ta) strong depletion, and enriched LREE patterns with strong negative Eu anomaly, and its genesis may be related to partial melting of the overlying crust induced by the upwelling of asthenosphere mantle or mafic magma underplating in the Early Cretaceous.