Abstract: Qujia gold deposit is located in the middle of Jiaojia gold deposit belt, which is an important altered rock type gold ore concentration area in China. and the elevation of the deposit is -726 m ~ -1334 m. In order to study the evolution of pyrite and its indication of the gold mineralization process, LA-ICP-MS was used to analyze the in-situ trace element content of pyrite, and, and the pyrite was classified by petrographic observation and cluster analysis.It is found that the trace elements such as Co, Ni and As in pyrite are mainly in the form of isomorphism, while elements such as Au, Ag, Cu, Zn, Pb and Bi are mainly in the form of nano-scale and micro-scale mineral inclusions. Pyrite is mainly divided into five types, Co-rich Py1, Ni-rich Py2, Au and As-rich Py3, Au, Ag, Pb, Bi-rich Py4 and 'clean 'Py5. The characteristics of trace elements of pyrite indicate that the ore-forming material may be mainly derived from the Precambrian metamorphic basement rocks and Mesozoic magmatic rocks, and a small amount from the mantle. The ore-forming hydrothermal solution may be a mixed genesis of metamorphic hydrothermal solution, magmatic hydrothermal solution and shallow atmospheric precipitation. Different types of pyrite reflect the evolution of ore-forming hydrothermal fluid from rich Co and Ni to rich As and Au to rich Pb, Bi, Au and Ag. After the formation of Py1 and Py2, they were strongly broken by tectonic activities, the enhanced adsorption of gold complexes in hydrothermal fluid on the fracture surface promotes the precipitation of gold in fractures, which may play an important role in the enrichment and mineralization of gold. The low content of Co and Ni in pyrite and the high content of Au, Ag, As, Pb and Bi in pyrite are closely related to mineralization. In addition, the content of Co and Ni in pyrite is high, but the crushing is strong, and the content of ore-forming related elements is high, which are the characteristics of pyrite formed in the early stage and transformed by the later mineralization.