In order to study the effect of magnesium-iron-manganese-zirconium quaternary hydrotalcite (MgFeMnZr-LDH) on the passivation remediation of antimony (Sb)-contaminated soils, MgFeMnZr-LDH was added to the yellow soil with a Sb content of 1 450 mg/kg and for 45 d of flooding, and NaH₂PO₄, Na₂HPO₄ and ethylenediaminetetraacetic acid (EDTA) were used to extract soil available Sb(Ⅲ) and Sb(Ⅴ); different forms of Sb(Ⅲ) and Sb(Ⅴ) in soil were extracted by Wenzel sequential extraction procedure; the correlation between the addition of MgFeMnZr-LDH, soil available Sb and different forms of Sb were discussed, and the passivation mechanism of MgFeMnZr-LDH on soil Sb was explored. The results showed that with the increase of MgFeMnZr-LDH addition, the total content of available Sb extracted by Na₂HPO₄, NaH₂PO₄ and EDTA gradually decreased, with maximum reduction rates of 26.5%, 25.2%, and 35.5%, respectively, in which the percentage of available Sb(Ⅲ) also decreased gradually; soil content of Sb (Ⅲ) and Sb(Ⅴ) decreased significantly in the non-specifically adsorption state(F1), the specifically adsorption state(F2), and the amorphous iron and aluminium oxide-bound state(F3), and increased significantly in the crystallized iron and aluminium oxide-bound state(F4); F3 and F4 had the largest variation in percentage. The material additions showed highly significant negative correlation with F1, F2, F3 of Sb(Ⅲ) and Sb(Ⅴ), highly significant positive correlation with F4 of Sb(Ⅲ) and Sb(Ⅴ), and significant positive correlation with the residual phases Sb(Ⅲ)(F5)in the soils. MgFeMnZr-LDH gradually transformed F1, F2 and F3 of Sb in soils into F4 and F5 through electrostatic, ion exchange, coordination, precipitation and oxidation, which reduced the bioeffectiveness of Sb and realized the passivation remediation of Sb-contaminated soil.