The late Mesoproterozoic igneous rocks in the western margin of Yangtze Block are important for understanding the tectonic evolution and its role in reconstruction of the Rodinia supercontinent. In this paper, we report new zircon U-Pb ages, whole rock major and trace elements, and Nd-Hf isotopic analyses of the plagioclase amphibolites and granites in the Cuoke area on the western margin of the Yangtze Block. Geochronological results show that the granites and plagioclase amphibolites have similar late Mesoproterozoic zircon U-Pb ages of 1 160.5 Ma and 1 170.2 Ma, constituting a bimodal igneous assemblage. The plagioclase amphibolites belong to the tholeiite series and characterized by enrichment in LREEs and LILEs, and have OIB-like affinities with No obvious Nb and Ta anomalies, and with positive εNd(t) and εHf(t) values, indicating that they were derived from the asthenospheric mantle source. The granites belong to the peralkaline A-type series and characterized by have high Fe/Mg and Ga/Al ratios, with positive εNd(t) value and εHf(t) values, indicating that they were derived partially from the newly formed crust. Geochemical characteristics indicate that the Cuoke plagioclase amphibolite and granite were likely formed in an intra-plate rift basin on the passive continental margin, and are unrelated to the Grenvillian Orogen in the western Yangtze Block. Based on previous research results, it is believed that the western margin of the Yangtze Block during the late Mesoproterozoic belonged to a passive continental margin rift environment, and the Yangtze Block was in the peripheral rather in the center in the configuration of Rodinia.